Synapses are constantly changing in the human brain, especially during key developmental time points and often in response to activity. The mechanisms by which synapse formation, disintegration and pruning are managed are still not entirely clear. Kimberly McAllister’s lab works on this topic, seeking to identify and characterize the molecules involved in synaptic regulation. Among […]
Category Archives: Synaptic Plasticity
The Role of Major Histocompatability Complex Class I in Cortical Synapse Development & Function
posted by UCSDNeuro
Making Memories: The Role of Activity-Dependent CRTC1 in Synapse-to-Nucleus Signaling
posted by UCSDNeuro
How does a memory come to be With so many synapses in a dendritic tree? With umpteen connections betwixt cells, How does a nucleus come to tell When and which genes transcribed will be Sufficient to mediate plasticity? The Martin Lab at UCLA Believes that they have found a way. When transmitter binding allows calcium […]
Forming Functional Synapses
posted by Ashley Juavinett
Since the discovery of long-term potentiation by Lomo and Bliss in 1973, neuroscientists have been searching for additional evidence of neuronal change based on experience. The concept of synaptic plasticity – the brain’s ability to change and adapt as a result of incoming information – is not new to the neuroscience field. But now, with […]
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