Tag Archives: optogenetics

December 10

A Toast to Optogenetics

[En español] “This seems rather far-fetched but it is conceivable that molecular biologists could engineer a particular cell type to be sensitive to light.” These words, published in 1999 by Francis Crick [1] (co-discoverer of the DNA double helix structure and a neuroscientist later in life) were incredibly prophetic. It did seem far-fetched, and yet, a […]

April 07

Wave makers: The origins of corticothalamic slow oscillations

It might come as a surprise that while you’re asleep or at rest your neurons do not enjoy a similar period of tranquil inactivity, but instead remain hard at work. In fact, previous studies report that coordinated waves of slow oscillatory activity (< 1 Hz) spread through the cortex and thalamus during sleep, waking rest […]

How mice decide: Stimulation of striatal D1 and D2 neurons bias choice in opposite ways

“It is our choices, Harry, that show us what we truly are, far more than our abilities.”  –Dumbledore “We are our choices.” –Jean-Paul Sartre  The question of how animals make decisions based upon prior experiences has plagued neuroscience since the field’s inception. An animal wants to make a decision in such a manner that it […]