Synapses are constantly changing in the human brain, especially during key developmental time points and often in response to activity. The mechanisms by which synapse formation, disintegration and pruning are managed are still not entirely clear. Kimberly McAllister’s lab works on this topic, seeking to identify and characterize the molecules involved in synaptic regulation. Among […]
Author Archives: UCSDNeuro
The Role of Major Histocompatability Complex Class I in Cortical Synapse Development & Function
posted by UCSDNeuro
Making Memories: The Role of Activity-Dependent CRTC1 in Synapse-to-Nucleus Signaling
posted by UCSDNeuro
How does a memory come to be With so many synapses in a dendritic tree? With umpteen connections betwixt cells, How does a nucleus come to tell When and which genes transcribed will be Sufficient to mediate plasticity? The Martin Lab at UCLA Believes that they have found a way. When transmitter binding allows calcium […]
RNA Alternative Splicing and Abundance: Using HITS-CLIP to Study the Function of RNA-Binding Proteins
posted by UCSDNeuro
Paraneoplastic neurologic disorders (PNDs) represent a rare class of neurodegenerative diseases that arise in the presence of cancer. The disorders are believed to stem from an immune response against certain tumor and neuronal antigens (onconeural antigens). The generation of onconeural antigens is a double-edged sword—while acting as an effective antitumor response, the antigens also generate […]
Noise vs song, how are naturalistic stimuli processed in the brain?
posted by UCSDNeuro
One problem encountered in researching sensory systems is that classical stimuli used to probe a sensory system are often not representative of what that system might encounter in the real world. Furthermore it has been difficult to explain the response of neurons to such naturalistic stimuli (such as natural scenes, faces, or speech) based solely […]
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